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Endocrine overactivity may be caused by the presence of primary pigmented nodular adrenocortical disease resulting in the Cushing syndrome, pituitary adenoma resulting in acromegaly, or sexual precocity associated with testicular lesions, particularly large cell calcifying Sertoli cell tumor

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Similarly, the STEP 5 trial demonstrated even greater results, with participants achieving a mean weight loss of -15.2% after two years (104 weeks)

Similar to global Glp1r/ mice, animals with deletion of the GLP-1R in vagal afferent/efferent nerves, Phox2b-Cre Glp1r flox/flox , as well as animals with a deletion of the GLP-1R in the CNS, nestin- Cre Glp1r flox/flox , maintain a similar body weight and food intake as control mice on both chow and HFD (Sisley et al., 2014)